Meaning : Direct or control. Projects, businesses, etc..
She is running a relief operation in the Sudan.
Synonyms : run
Meaning : Perform as expected when applied.
The washing machine won't go unless it's plugged in.
Does this old car still run well?.
This old radio doesn't work anymore.
Meaning : Handle and cause to function.
Do not operate machinery after imbibing alcohol.
Control the lever.
Synonyms : control
Meaning : Perform surgery on.
The doctors operated on the patient but failed to save his life.
Synonyms : operate on