Example : Debt-ridden farmers struggling with adversity.
A life of hardship.

Synonyms : adversity, hard knocks

Example : The asperity of northern winters.

Synonyms : asperity, grimness, rigor, rigorousness, rigour, rigourousness, severeness, severity

Example : I cannot think it a hardship that more indulgence is allowed to men than to women.
The many hardships of frontier life.